NPPA outcome data 2022/23

This is a list of decisions on NPPA applications with their outcomes. We've included the indication where it would not compromise anyone's privacy.

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	Medicine		Approved	Declined	Principles not met	Withdrawn application	Total
	adalimumab		11			2	13
		Indication
		chronic recurrent multifocal osteomyelitis	4				4
		Other indication(s)	7			2	9
	alpha tocopheryl acetate		49			1	50
		Indication
		cystic fibrosis (CF)	4				4
		liver disease or short gut syndrome	36				36
		liver disease or short gut syndrome, Biliary Atresia	1				1
		Liver disease, EBV infection, Oral liquid required (child)	1				1
		other indication(s)	7			1	8
	anakinra		9			1	10
		Indication
		other indication(s)	9			1	10
	asparaginase		7				7
		Indication
		ALL	4				4
		other indication(s)	3				3
	atezolizumab				6	1	7
		Indication
		Other indication(s)			6	1	7
	azacitidine		5				5
		Indication
		Other indication(s)	5				5
	azithromycin		1		1	2	4
		Indication
		Other indication(s)	1		1	2	4
	bedaquiline		11				11
		Indication
		Multi-drug resistant (MDR) tuberculosis (TB)	5				5
		Other indication(s)	6				6
	bevacizumab		9		6		15
		Indication
		Other indication(s)	9		6		15
	biotin		6				6
		Indication
		Other indication(s)	6				6
	blinatumomab		7			1	8
		Indication
		B-ALL	4			1	5
		Other indication(s)	3				3
	brentuximab vedotin		17		1		18
		Indication
		Other indication(s)	4				4
		relapsed/refractory CD30-positive Hodgkin lymphona	13		1		14
	canakinumab		4				4
		Indication
		Other indication(s)	4				4
	cannabinoid		3		10	1	14
		Indication
		Epilepsy			3	1	4
		Other indication(s)	3		7		10
	ciclosporin eye preparations		85		1	1	87
		Indication
		allergic conjunctivitis	2				2
		allergic conjunctivitis, keratoconjunctivitis sicca	1				1
		allergic eye disease	2				2
		allergic eye disease, limbitis, reactive fibrovascular growth to temporal conjunctiva	1				1
		allergic eye disease, Sjogren's syndrome	1				1
		allergic keratoconjunctivitis	1				1
		allergic keratoconjunctivitis, giant papillarly conjunctivitis	1				1
		atopic conjunctivitis	1				1
		atopic conjunctivitis, allergic conjunctivitis	2				2
		atopic keratoconjunctivitis	4			1	5
		atopic keratoconjunctivitis, limbitis	1				1
		bilateral keratoconus, corneal graft, giant papillarly conjunctivitis	1				1
		Bilateral Superior Conjunctival Epithelium Growth	1				1
		Blepharitis, ocular rosacea, meibomian gland dysfunction	1				1
		blepharokeratoconjunctivitis	2				2
		corneal neovascularisation	1				1
		dry eyes	1				1
		dry eyes, ocular surface inflammation	1				1
		dry eyes, ocular surface inflammation, NOT RARE DISORDER - REPORTING PURPOSES ONLY	1				1
		Graft vs Host Disease	1				1
		Inferior punctuate erosions	1				1
		keratoconjunctivitis sicca	5				5
		keratoconjunctivitis sicca, allergic conjunctivitis	1				1
		keratoconjunctivitis sicca, dry eyes	1				1
		keratoconjunctivitis sicca, severe dry eye	2				2
		keratoconjunctivitis sicca, severe dry eyes	2				2
		keratoconjunctivitis sicca, Sjogren's syndrome	2				2
		marginal keratitis, Blepharitis, meibomian gland dysfunction	1				1
		meibomian gland dysfunction	1				1
		neuropathic keratopathy, corneal scarring	1				1
		ocular graft vs host disease	1				1
		ocular inflammation	1				1
		other indication(s)	1				1
		rosacea keratitis	1				1
		severe allergic conjunctivitis	2				2
		severe dry eye	1				1
		severe dry eye, NOT RARE DISORDER - REPORTING PURPOSES ONLY	1				1
		severe dry eyes, Sjogren's syndrome	1				1
		severe keratoconjunctivitis sicca	3				3
		Severe ocular rosacea	1				1
		severe secretory dry eye	4				4
		severe secretory dry eye, connective tissue disorder, Sjogren's syndrome			1		1
		severe secretory dry eye, NOT RARE DISORDER - REPORTING PURPOSES ONLY	1				1
		severe secretory dry eye, rheumatoid arthritis, Sjogren's syndrome	1				1
		severe secretory dry eye, RhF positive	1				1
		vernal blepharoconjunctivitis	1				1
		vernal conjunctivitis, keratitis, veratoconus	1				1
		vernal keratoconjunctivitis (VKC)	19				19
	cinacalcet				2	2	4
		Indication
		other indication(s)			2	2	4
	continuous glucose monitoring system		8		6	2	16
		Indication
		Other indication(s)	7		1	2	10
		type 1 diabetes	1		5		6
	dabrafenib		5			1	6
		Indication
		other indication(s)	5			1	6
	dasatinib		3			1	4
		Indication
		Other indication(s)	3			1	4
	deferasirox		4		2	1	7
		Indication
		iron overload	3		1		4
		Other indication(s)	1		1	1	4
	denosumab		5		5		10
		Indication
		Giant cell tumour of the bone	4		1		5
		Other indication(s)	1			4	5
	dupilumab		3		1		4
		Indication
		Other indication(s)	3		1		4
	eculizumab		2	1	1	1	5
		Indication
		Other indication(s)	2	1	1	1	5
	eltrombopag		3			1	4
		Indication
		Other indication(s)	3			1	4
	enoxaparin sodium		4			2	6
		Indication
		Other indication(s)	4			2	6
	etanercept		2		1	1	4
		Indication
		Other indication(s)	2		1	1	4
	fenfluramine		3		1		4
		Indication
		dravet's syndrome	3		1		4
	galcanezumab		1		3		4
		Indication
		chronic migraine	1		3		4
	ganciclovir eye preparations		4				4
		Indication
		Cytomegalovirus (CMV) uveitis	4				4
	ibrutinib		1		6		7
		Indication
		other indication(s)	1		6		7
	imiglucerase		5				5
		Indication
		Gaucher's Disease	5				5
	indomethacin		4				4
		Indication
		other indication(s)	4				4
	infliximab		7		4		11
		Indication
		Other indication(s)	7		4		11
	inotuzumab ozogamicin		4				4
		Indication
		Other indication(s)	4				4
	insulin pump consumables		3			4	7
		Indication
		other indication(s)	1			2	3
		Type 1 diabetes	2			2	4
	ivabradine		1		4	1	6
		Indication
		atrial tachycardias	1				1
		inappropriate sinus tachycardia			4	1	5
	ketamine		8				8
		Indication
		pallative care pain	8				8
	lamotrigine		10		5	1	16
		Indication
		Epilepsy	10		3	1	14
		Other indication(s)			2		2
	lenalidomide		6		1		7
		Indication
		myelodysplastic syndrome with 5q deletion	4				4
		Other indication(s)	2		1		3
	levetiracetam		31			1	32
		Indication
		palliative care, Seizures	31			1	32
	levocarnitine		2		1		3
		Indication
		other indication(s)	2		1		3
	linezolid		7			1	8
		Indication
		Multi-drug resistant (MDR) tuberculosis (TB)	6				6
		Other indication(s)	1			1	2
	liraglutide				6		6
		Indication
		Obesity, high BMI			6		6
	macitentan		7		3	1	11
		Indication
		other indication(s)	2				2
		Pulmonary hypertension (PAH)	5		3	1	9
	melatonin				4		4
		Indication
		other indication(s)			4		4
	mepolizumab		2		2		4
		Indication
		other indication(s)	2		2		4
	mitotane		10				10
		Indication
		adrenocortical carcinoma	10				10
	moxifloxacin		4		1	1	6
		Indication
		other indication(s)	4		1	1	6
	nelarabine		4		1		5
		Indication
		Acute Lymphocytic leukaemia	4		1		5
	nirmatrelvir with ritonavir		1		2	5	8
		Indication
		COVID-19	1		2	5	8
	octreotide lar		4			1	5
		Indication
		Other indication(s)	4			1	5
	olaparib		12		1		13
		Indication
		BRCA2 mutation, metastatic breast cancer	5				5
		Other indication(s)	7			1	8
	omalizumab		2		1	1	4
		Indication
		Other indication(s)	2		1	1	4
	pazopanib		3		2		5
		Indication
		Other indication(s)	3		2		5
	pembrolizimab		9		11	1	21
		Indication
		other indication(s)	2		11	1	14
		placental trophoblastic tumour	1				1
		relapsed Hodgkin's lymphoma	6				6
	pirfenidone				1	3	4
		Indication
		other indication(s)			1	3	4
	posaconazole		9		1		10
		Indication
		Other indication(s)	9		1		10
	pristinamycin		7				7
		Indication
		Mycoplasma genitalium infection	6				6
		Other indication(s)	1				1
	prucalopride		6		6	1	13
		Indication
		chronic constipation			5		5
		severe gastroparesis	6		1	1	8
	retinol (vitamin a)		55				55
		Indication
		liver disease or short gut syndrome	46				46
		other indication(s)	9				9
	rituximab		26		5	3	34
		Indication
		Other indication(s)	26		5	3	34
	rufinamide		7		1		8
		Indication
		Other indication(s)	1				1
		refractory epilepsy	6		1		7
	ruxolitinib		4		2		6
		Indication
		Graft versus host disease	3		2		5
		Other indication(s)	1				1
	sargramostim		4				4
		Indication
		High risk neuroblastom	4				4
	secukinumab		7		3		10
		Indication
		Other indication(s)	7		3		10
	sirolimus		4				4
		Indication
		Other indication(s)	4				4
	sunitinib		2		1	1	4
		Indication
		Other indication(s)	2		1	1	4
	tacrolimus ointment		1			4	5
		Indication
		other indication(s)	1			4	5
	tadalafil		3		3	1	7
		Indication
		Other indication(s)	1				1
		Pulmonary arterial hypertension (PAH)	2		3	1	6
	temozolomide		10		3		13
		Indication
		Highr risk neuroblastoma	4				4
		other indication(s)	6		3		9
	thalidomide		4		1		5
		Indication
		other indication(s)	4		1		5
	tocilizumab		7		9	1	17
		Indication
		Giant cell arteritis	1		4		5
		Other indication(s)	6		5	1	12
	topotecan		5				5
		Indication
		High risk neuroblastoma	5				5
	trametinib		16		1	1	18
		Indication
		neurofibromatosis type 1	4		1		5
		Other indication(s)	12			1	13
	upadacitinib		12		5	1	18
		Indication
		Other indication(s)	3		3	1	7
		severe atopic dermatitis	9		2		11
	ustekinumab		1		3		4
		Indication
		Other indication(s)	1		3		4
	valganciclovir		4				4
		Indication
		Cytomegalovirus (CMV)	4				4
	varicella zoster virus				5	1	6
		Indication
		shingles prevention			5	1	6
	venetoclax		5		5	1	11
		Indication
		Acute myeloid leukaemia (AML)	3			1	4
		Other indication(s)	2		5		7
	voriconazole		7			1	8
		Indication
		chronic aspergillosis	4				4
		Other indication(s)	3			1	4
	zonisamide		8		1		9
		Indication
		refractory epilepsy	8		1		9