NPPA outcome data 2021/22

This is a list of decisions on NPPA applications with their outcomes. We've included the indication where it would not compromise anyone's privacy.

Download the data as a spreadsheet (includes medicines, outcomes and some indications)

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Outcomes of applications by medicine 2021/22



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Medicine   Approved Declined Principles not met Withdrawn application Total
acetic acid 1 1
acetylcysteine 1 1 2
adalimumab 3 2 3 8
Indication  
Anxiety 1 1
Crohn's disease 1 1
Type 1 diabetes 1 1
Other indication(s) 3 1 1 5
               
adalimumab (Amgevita) 1 1
aflibercept 1 1
alectinib 1 1 2
alglucosidase alfa 2 2
alirocumab 1 1 2
alitretinoin 3 3
Indication  
Dermatitis 2 2
Other indication(s) 1 1
               
alpha tocopheryl acetate 2 2
Indication  
Pancreatic insufficiency 2 2
               
alpha tocopheryl acetate (Micelle E) 1 1
amantadine hydrochloride 1 1
ambrisentan 1 1
Indication  
Pulmonary hypertension 1 1
               
amifampridine [3,4-diaminopyridine] 2 2
amikacin 1 1
amiloride hydrochloride 1 1
amino acid formula (without isoleucine, leucine and valine) 6 6
Indication  
Short-chain enoyl-CoA hydratase deficiency 4 4
Leigh syndrome 2 2
               
amino acid formula (without methionine) (hcu lophlex lq20) 1 1
amino acid formula low calcium (Locasol) 4 4
Indication  
Hypercalcaemia 4 4
               
anakinra 5 1 1 7
apixaban 1 1
aprepitant 3 1 1 5
Indication  
Intractable nausea 3 1 4
Other indication(s) 1 1
               
arginine 1 1
aripiprazole 1 1
Indication  
Schizoaffective Disorder 1 1
               
aripiprazole 1 1
asfotase alpha 1 1
asparaginase (Erwinase) 1 1
atezolizumab 6 6
Indication  
Metastatic colon cancer 2 2
Other indication(s) 4 4
               
atovaquone 1 1
azacitidine 9 1 1 11
Indication  
Acute myeloid leukaemia (AML) 1 1
Chronic myelomonocytic leukemia (CMML) 1 1 2
Myelodysplasia 3 3
Other indication(s) 5 5
               
azithromycin 2 1 3
Indication  
Cystic fibrosis (CF) 1 1
Other indication(s) 1 1 2
               
bedaquiline 8 1 9
Indication  
Multi-drug resistant (MDR) tuberculosis (TB) 6 1 7
Other indication(s) 2 2
               
belimumab 3 3
Indication  
Lupus nephritis 2 2
Other indication(s) 1 1
               
bendamustine hydrochloride 1 1 2
bevacizumab 2 1 1 4
Indication  
Ovarian Cancer 1 1
Other indication(s) 2 1 3
               
bilastine 1 1
bimatoprost preservative free 1 1
biotin 1 1
blinatumomab 3 3
Indication  
B-Cell Acute Lymphoblastic Leukaemia 3 3
               
bortezomib 2 2
Indication  
Epstein Barr Virus 1 1
Other indication(s) 1 1
               
bosutinib 1 1
Indication  
Chronic myeloid leukemia (CML) 1 1
               
brentuximab vedotin 2 3 5
bromocriptine 1 1
bromocriptine mesylate 1 1
budesonide 2 2 4
buprenorphine 1 1
burosumab 2 2
cannabinoid 1 7 1 9
Indication  
Anxiety 2 2
Epilepsy 1 1
Other indication(s) 1 4 1 6
               
cefiderocol 2 2
ceftazidime and avibactam 1 1
ceftolozane/tazobactam 1 1
chloramphenicol 1 1
ciclosporin eye preparations 56 1 1 58
Indication  
Atopic keratoconjunctivitis 5 5
Dry eyes 3 1 4
Keratoconjunctivitis sicca 16 16
Ocular inflammation 2 2
Reis-Bucklers corneal dystrophy 4 4
Severe dry eyes 6 6
Sjogren's syndrome 4 1 5
Vernal keratoconjunctivitis (VKC) 7 7
Other indication(s) 9 9
               
cinacalcet 2 5 7
Indication  
Hypercalcaemia 1 1
Hyperparathyroidism 1 5 6
               
citrulline 1 1
clofarabine 1 1
Indication  
Acute myeloid leukaemia (AML) 1 1
               
cobimetinib 1 1
Indication  
Metastatic melanoma 1 1
               
coenzyme q10 1 1
colesevelam 1 1
colistin sulphomethate 1 1
continuous glucose monitoring system (Dexcom glucose transmitters and sensors) 2 1 3
Indication  
Type 1 diabetes 1 1 2
Other indication(s) 1 1
               
continuous glucose monitoring system (Dexcom g6 alarmed interstitial glucose sensor) 1 1
continuous glucose monitoring system (Dexcom G6 sensors) 1 1
continuous glucose monitoring system (Dexcom G6 transmitter) 1 1
continuous glucose monitoring system (Dexcom) 2 2
Indication  
Type 1 diabetes 2 2
               
continuous glucose monitoring system (Freestyle Libre) 1 1
Indication  
Anxiety 1 1
               
continuous glucose monitoring system (FreeStyle Libre: Flash Glucose Monitoring System) 1 1
continuous glucose monitoring system (Guardian Connect transmitter) 1 1
continuous glucose monitoring system (Guardian Sensor 3) 1 1
cyanocobalamin (Vitamin B12) 1 1
cyclopentolate eye preperations 1 1
dabrafenib 3 3
Indication  
Metastatic melanoma 2 2
Ovarian Cancer 1 1
               
danazol 4 4
Indication  
Hereditary angioedema 2 2
Other indication(s) 2 2
               
daratumumab 1 1
deferasirox 1 2 3
deferiprone 2 2
degarelix 1 1
demeclocycline hydrochloride 1 1 2
Indication  
Hyponatraemia 1 1
Other indication(s) 1 1
               
denosumab 5 4 1 10
Indication  
Giant cell tumour of the bone 5 5
Hypercalcaemia 1 1
Osteoporosis 3 3
Other indication(s) 1 1
               
desogestrel 1 1
Indication  
Other indication(s) 1 1
               
dexamethasone eye preparations (Ozurdex) 2 2
diphenoxylate hydrochloride with atropine sulphate 1 1
dipyridamole 4 4
Indication  
Nephrotic Syndrome 4 4
               
dulaglutide 1 1 1 3
Indication  
Type 2 diabetes 1 1
Other indication(s) 1 1 2
               
duloxetine 1 1
Indication  
Anxiety 1 1
               
dupilumab 2 1 3
Indication  
Dermatitis 1 1 2
Other indication(s) 1 1
               
eculizumab 2 1 3
elexacaftor/tezacaftor/ivacaftor 1 1
eltrombopag 1 3 1 5
emicizumab 2 1 3
emollient (Octenisan) 1 1
empagliflozin 5 5
Indication  
Heart failure 3 3
Type 2 diabetes 2 2
               
emtricitabine with tenofovir alafenamide 2 2
enoxaparin sodium 4 2 6
enteral feed (Liquid Hope) 1 1
enteral feed paediatric (Compleat) 1 1
entrectinib 1 1
Indication  
Ovarian Cancer 1 1
               
eplerenone 1 1 2
epoetin alfa 1 1 2
Indication  
Chronic myelomonocytic leukemia (CMML) 1 1
Other indication(s) 1 1
               
eptacog alfa [recombinant factor viia] 1 1
erenumab 1 1
eribulin 1 1
Indication  
Breast cancer 1 1
               
etanercept 2 1 1 4
etoricoxib 2 2
everolimus 1 1 2
Indication  
Neuroendocrine tumour 1 1
Other indication(s) 1 1
               
evolocumab 1 2 3
fexofenadine hydrochloride 1 1
filgrastim 1 1
fish oil (PharmEPA Complete) 1 1
flunarizine 1 1
fluoxetine hydrochloride 1 1 2
Indication  
Anxiety 1 1
Depression 1 1
               
fluphenazine decanoate 1 1
Indication  
Schizophrenia 1 1
               
fluvoxamine maleate 1 1
fostamatinib 1 1
gabapentin 1 2 3
Indication  
Epilepsy 1 1
Other indication(s) 2 2
               
ganciclovir 1 1
Indication  
Cytomegalovirus (CMV) 1 1
               
ganciclovir eye preparations 3 1 4
Indication  
Cytomegalovirus (CMV) 3 3
Other indication(s) 1 1
               
gemtuzumab ozogamicin 2 2
Indication  
Acute myeloid leukaemia (AML) 1 1
Other indication(s) 1 1
               
glycopyrrolate 1 1
goserelin (Zoladex) 1 1
Indication  
Breast cancer 1 1
               
hydrocortisone acetate (rectal foam) (Cortifoam) 1 1
ibrutinib 2 1 3
icatibant 1 1
idebenone 1 1
indomethacin 5 5
Indication  
Nephrotic Syndrome 4 4
Other indication(s) 1 1
               
infliximab 7 3 2 12
Indication  
Chronic lymphocytic leukaemia (CLL) 1 1
Crohn's disease 1 1
Ulcerative Colitis 1 1
Other indication(s) 4 2 2 8
Anxiety 1 1
               
insulin pump 1 2 3
Indication  
Type 1 diabetes 1 2 3
               
ipilimumab 1 1
i-port (I-Port) 1 1
Indication  
Type 2 diabetes 1 1
               
isoleucine 2 2
Indication  
Leigh syndrome 1 1
Short-chain enoyl-CoA hydratase deficiency 1 1
               
ivabradine 3 3 6
Indication  
Heart failure 1 1
Other indication(s) 2 3 5
               
ketamine 5 1 6
Indication  
Pain management 4 4
Other indication(s) 1 1 2
               
ketotifen 2 2
lamotrigine 2 1 15 2 20
Indication  
Epilepsy 2 1 10 11
Mental health 3 2 5
Other indication(s) 2 2
               
lanadelumab 1 1 2
Indication  
Hereditary angioedema 1 1 2
               
lanreotide 2 1 3
Indication  
Neuroendocrine tumour 1 1 2
Other indication(s) 1 1
               
lenalidomide 4 3 7
Indication  
Myelodysplasia 1 3 4
Other indication(s) 3 3
               
lenolidamide 1 1
lenvatinib 1 1
letermovir 2 2
Indication  
Cytomegalovirus (CMV) 2 2
               
leucine 2 2
Indication  
Leigh syndrome 1 1
Short-chain enoyl-CoA hydratase deficiency 1 1
               
leuprorelin acetate 1 1
levetiracetam 2 1 3
Indication  
Epilepsy 1 1
Other indication(s) 2 2
               
levocarnitine 1 1
Indication  
Epilepsy 1 1
               
levocarnitine (Carnitor) 1 1
levocetirizine 1 1
levofloxacin 1 1
Indication  
Multi-drug resistant (MDR) tuberculosis (TB) 1 1
               
levofloxacin (Dr Reddy's) 1 1
lidocaine [lignocaine] 1 1
linezolid 8 8
Indication  
Cystic fibrosis (CF) 1 1
Multi-drug resistant (MDR) tuberculosis (TB) 5 5
Other indication(s) 2 2
               
liraglutide 1 1
Indication  
Anxiety 1 1
               
luspatercept 1 1
macitentan 2 2
Indication  
Pulmonary hypertension 2 2
               
megestrol acetate 1 1
melatonin 1 2 3
mepolizumab 3 3
methylphenidate hydrochloride 1 1 2
metolazone 1 1
Indication  
Heart failure 1 1
               
metronidazole 1 1
Indication  
Breast cancer 1 1
               
midostaurin 1 1 1 3
Indication  
Acute myeloid leukaemia (AML) 1 1
Other indication(s) 1 1 2
               
migalastat 1 1
miglustat 3 3
mirabegron 1 1
mitotane 2 2
moxifloxacin 3 3
Indication  
Multi-drug resistant (MDR) tuberculosis (TB) 3 3
               
multiple sclerosis 1 1
multivitamin and mineral supplement (Clinicians Multivitamin and Mineral Boost) 1 1
mycophenolic acid 1 1
naltrexone hydrochloride 1 1
nelarabine 1 1
nimodipine 2 2
nintedanib 1 1 2
Indication  
Lung Disease 1 1
Other indication(s) 1 1
               
nirmatrelvir with ritonavir (Paxlovid) 1 1
Indication  
COVID-19 1 1
               
nitazoxanide (Alinia) 1 1
nivolumab 3 1 4
Indication  
Metastatic colon cancer 1 1
Other indication(s) 2 1 3
               
octreotide lar 3 2 5
Indication  
Neuroendocrine tumour 3 3
Other indication(s) 2 2
               
oestradiol 1 1
oestradiol valerate 1 1
olanzapine (Zyprexa Zydis) 1 1
omadacycline 1 1
Indication  
Cystic fibrosis (CF) 1 1
               
omeprazole 1 1
oral feed liquid (Fortisip or Ensure Plus) 1 1
oral feed liquid fat-free (Fortijuce) 2 2
oral feed paediatric renal (Renastart) 7 7
Indication  
Renal disease 7 7
               
oral supplement elemental with high medium chain triglyceride (Emsogen) 1 1
orlistat 1 1
oseltamivir 1 1
oxandrolone 1 1
oxcarbazepine (Trileptal) 1 1
oxybutynin 1 1
palbociclib 1 1
paliperidone 5 5
Indication  
Schizoaffective Disorder 1 1
Schizophrenia 2 2
Other indication(s) 2 2
               
palivizumab 1 3 2 6
Indication  
Heart failure 1 1
Other indication(s) 3 2 5
               
paracetamol 1 1
paraldehyde 1 1
Indication  
Epilepsy 1 1
               
parecoxib 1 1
paromomycin 3 3
Indication  
Metronidazole resistant trichomoniasis 1 1
Other indication(s) 2 2
               
paroxetine 1 1
pazopanib 3 1 1 5
pegylated interferon alfa-2a 3 1 4
Indication  
Chronic myeloid leukemia (CML) 1 1
Other indication(s) 3
               
pegylated interferon 1 1
pegylated liposomal doxorubicin hydrochloride 1 3 4
Indication  
Ovarian Cancer 3 3
Other indication(s) 1 1
               
pembrolizimab 6 10 16
Indication  
Metastatic colon cancer 3 3
Other indication(s) 6 7 13
               
perampanel 4 4
Indication  
Epilepsy 3 3
Other indication(s) 1 1
               
pertuzumab 1 1 2
Indication  
Breast cancer 1 1 2
               
phenelzine sulphate 1 1
Indication  
Depression 1 1
               
pimecrolimus 1 1
pirfenidone 1 1
plerixafor 1 1
polatuzumab vedotin 1 1
ponatinib 3 1 4
Indication  
Chronic myeloid leukemia (CML) 2 1 3
Other indication(s) 1 1
               
posaconazole 8 1 9
Indication  
Acute myeloid leukaemia (AML) 1 1
Aspergillus fumigatus 1 1
Other indication(s) 7 7
               
potassium chloride 1 1
potassium citrate 2 2
prednisolone sodium phosphate 1 1
pristinamycin 9 9
Indication  
Mycoplasma genitalium infection 5 5
Treatment resistant Mycoplasma genitalium infection 3 3
Other indication(s) 1 1
               
probiotics 1 1
Indication  
Pain management 1 1
               
prucalopride 2 2 1 5
Indication  
Hyperparathyroidism 1 1
Other indication(s) 1 2 1 4
               
quinacrine [mepacrine] 1 2 3
quinidine 1 1
rasburicase 1 1
retinol 1 1
ribavirin 1 2 3
rifaximin 1 1
riluzole 1 1
risankizumab 1 1
Indication  
Severe chronic plaque psoriasis 1 1
               
risdiplam 1 1
rituximab 38 7 5 45
Indication  
Chronic lymphocytic leukaemia (CLL) 1 1
Chronic myeloid leukemia (CML) 1 1
Epilepsy 1 1
Epstein Barr Virus 1 1
Lung Disease 1 1
Lupus nephritis 2 2
Nephrotic Syndrome 4 4
Ocular inflammation 1 1
Other indication(s) 31 3 4 34
               
rivastigmine 1 1
romiplostim 2 2
rosuvastatin 1 1
rufinamide 11 11
Indication  
Epilepsy 8 8
Other indication(s) 3 3
               
ruxolitinib 3 2 5
Indication  
Graft versus host disease 1 1 2
Other indication(s) 2 1 3
               
sapropterin dihydrochloride 1 1
secukinumab 3 1 2 6
Indication  
Chronic lymphocytic leukaemia (CLL) 1 1
Severe chronic plaque psoriasis 1 1
Other indication(s) 2 1 1 4
               
selegiline hydrochloride 1 1
selexipag 2 2
Indication  
Cystic fibrosis (CF) 1 1
Pulmonary hypertension 1 1
               
selumetinib 1 1
sildenafil 1 1
Indication  
Pulmonary hypertension 1 1
               
sirolimus 2 2 4
Indication  
Epstein Barr Virus 1 1
Other indication(s) 1 2 3
               
sirolimus ointment 6 6
Indication  
Facial angiofibromas 5 5
Other indication(s) 1 1
               
sitafloxacin 1 1
Indication  
Treatment resistant Mycoplasma genitalium infection 1 1
               
sodium benzoate 1 1
sodium chloride 4 1 5
Indication  
Epilepsy 1 1
Hyponatraemia 2 2
Other indication(s) 1 1 2
               
sodium phenylbutyrate 1 1
sofosbuvir with velpatasvir 2 2
somatropin 1 1
spiramycin 1 1
stanozolol 4 4
Indication  
Hereditary angioedema 4 4
               
sulthiame 1 1
sunitinib 1 1
tacrolimus 4 3
Indication  
Graft versus host disease 1 1
Other indication(s) 3 2
               
tacrolimus ointment 1 1
Indication  
Dermatitis 1 1
               
tacrolimus suppositories 1 1
tadalafil 3 1 4
Indication  
Depression 1 1
Other indication(s) 2 1 3
               
tafamidis 1 1
taurolidine and citrate 2 1 3
teduglutide 1 1 2
temozolomide 2 2
tenofovir alafenamide 1 1
terazosin 1 1
terbutaline 1 1
teriparatide 1 3 4
Indication  
Osteoporosis 2 2
Other indication(s) 1 1 2
               
tetracycline 1 1
thalidomide 3 3
ticagrelor 3 3
tinidazole 5 5
Indication  
Metronidazole resistant trichomoniasis 2 2
Other indication(s) 3 3
               
tirofiban 1 1
tizanidine 1 1
tobramycin 2 1 3
tocilizumab 48 3 4 55
Indication  
COVID-19 44 1 45
Giant cell arteritis 1 3 1 5
Lung Disease 1 1
Other indication(s) 3 1 4
               
tofacitinib 1 2 1 4
topotecan 1 1
trametinib 1 3 4
Indication  
Metastatic melanoma 2 2
Ovarian Cancer 1 1
Other indication(s) 1 1
               
trastuzumab subcutaneous 1 1
Indication  
Breast cancer 1 1
               
trientine hydrochloride 1 1
triiodothyroacetic acid 1 1
tyrosine 2 2
upadacitinib 2 2
Indication  
Dermatitis 1 1
Other indication(s) 1 1
               
uridine 2 2
ursodeoxycholic acid 1 1
ustekinumab 3 8 2 13
Indication  
Crohn's disease 2 5 2 9
Severe chronic plaque psoriasis 1 1
Ulcerative Colitis 1 1
Other indication(s) 1 1 2
               
valganciclovir 8 8
Indication  
Cytomegalovirus (CMV) 7 7
Epstein Barr Virus 1 1
               
vancomycin 1 1
varicella zoster virus (oka strain) live attenuated vaccine [shingles vaccine] (Zostavax) 1 1
vedolizumab 1 3 1 5
Indication  
Crohn's disease 1 1 2
Ulcerative Colitis 1 1
Other indication(s) 1 1 2
               
vemurafenib 1 1
Indication  
Metastatic melanoma 1 1
               
venetoclax 2 3 5
Indication  
Acute myeloid leukaemia (AML) 2 2
Chronic lymphocytic leukaemia (CLL) 1 1
Other indication(s) 1 1 2
               
venlafaxine 1 1
Indication  
Depression 1 1
               
vinorelbine 1 1
Indication  
Breast cancer 1 1
               
vitamin a - retinol 1 1
Indication  
Pancreatic insufficiency 1 1
               
voriconazole 7 7
Indication  
Aspergillus fumigatus 3 3
Other indication(s) 4 4
               
whole thyroid extract 1 1
zonisamide 11 1 12
Indication  
Epilepsy 10 1 11
Other indication(s) 1 1