NPPA outcome data 2020/24

This is a list of decisions on NPPA applications with their outcomes. We've included the indication where it would not compromise anyone's privacy.

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	Medicine		Approved	Declined	Principles not met	Withdrawn application	Total
	4-aminopyridine		5		2		7
		Indication
		other indication(s)	5		2		7
	adalimumab		24		6	10	40
		Indication
		chronic recurrent multifocal osteomyelitis	7				7
		other indication(s)	17		6	10	33
	alirocumab				12	2	14
		Indication
		hypercholesterolaemia			8	1	9
		other indication(s)			4	1	5
	alitretinoin		1		7	1	9
		Indication
		other indication(s)	1		7	1	9
	amifampridine [3,4-diaminopyridine]		7				7
		Indication
		other indication(s)	7				7
	amino acid formula		4		1	2	7
		Indication
		other indication(s)	4		1	2	7
	amino acid formula (without isoleucine, leucine and valine)		10				10
		Indication
		other indication(s)	3				3
		short-chain enoyl-CoA hydratase deficiency	7				7
	amino acid formula low calcium		8				8
		Indication
		hypercalcaemia	8				8
	anakinra		23		5	3	31
		Indication
		other indication(s)	23		5	3	31
	apixaban				6	1	7
		Indication
		other indication(s)			6	1	7
	aprepitant		12		3	1	16
		Indication
		intractable nausea or vomiting	8		2	1	11
		other indication(s)	4		1		5
	aripiprazole				6	1	7
		Indication
		Schizoaffective Disorder			6	1	7
	asparaginase		28			1	29
		Indication
		acute lymphocytic leukaemia (ALL)	7				7
		other indication(s)	6			1	7
		pegasparaginase allergy	15				15
	atezolizumab		1	1	16	1	19
		Indication
		other indication(s)	1	1	16	1	19
	azacitidine		27		1	2	30
		Indication
		acute myeloid leukaemia (AML)	8		1		9
		chronic myeloid leukemia (CML)	5			1	6
		myelodysplasia	9				9
		other indication(s)	5			1	6
	azithromycin		6		3	3	12
		Indication
		other indication(s)	6		3	3	12
	bedaquiline		35			2	37
		Indication
		multi-drug resistant (MDR) tuberculosis (TB)	18			2	20
		mycobacterium abscessus	17				17
	bendamustine hydrochloride		4		3		7
		Indication
		other indication(s)	4		3		7
	bevacizumab		29		13	1	43
		Indication
		hereditary haemorrhagic telangiectasia (HHT)	7		3		10
		other indication(s)	22		10	1	33
	biotin		14				14
		Indication
		other indication(s)	14				14
	blinatumomab		28		1	2	31
		Indication
		Acute Lymphoblastic Leukaemia (ALL)	11				11
		B-Cell Acute Lymphoblastic Leukaemia (B-ALL)	15		1	2	18
		other indication(s)	2				2
	bortezomib		11		1	1	13
		Indication
		other indication(s)	11		1	1	13
	brentuximab vedotin		38		8	1	47
		Indication
		Hodgkin's lymphoma	25		3		28
		Large cell lymphoma	5		2	1	8
		other indication(s)	1		3		4
		T cell lymphoma	7				7
	budesonide		2		4	1	7
		Indication
		other indication(s)	2		4	1	7
	cannabinoid		7		36	4	47
		Indication
		epilepsy	2		13	2	17
		other indication(s)	5		13	2	20
		pain			9		9
	ceftazidime and avibactam		9			1	10
		Indication
		other indication(s)	9			1	10
	ciclosporin eye preparations		241		7	1	249
		Indication
		dry eyes	241		7	1	249
	cinacalcet		3		16	6	25
		Indication
		hyperparathyroidism	2		15	4	21
		other indication(s)	1		1	2	4
	continuous glucose monitor		24		17	3	44
		Indication
		other indication(s)	17		5	2	24
		type 1 diabetes	7		12	1	20
	crizotinib		5		2		7
		Indication
		other indication(s)	5		2		7
	dabrafenib		12		4	1	17
		Indication
		other indication(s)	12		4	1	17
	danazol		8		3		11
		Indication
		other indication(s)	8		3		11
	daratumumab		2		5		7
		Indication
		other indication(s)	2		5		7
	deferasirox		4		4	4	12
		Indication
		other indication(s)	4		4	4	12
	denosumab		19		23	2	44
		Indication
		giant cell tumour of the bone	14				14
		hypercalcaemia	4		7	1	12
		osteoporosis			9		9
		other indication(s)	1		7	1	9
	dexamethasone eye preparations		1		8		9
		Indication
		other indication(s)	1		8		9
	dipyridamole		11				11
		Indication
		congenital nephrotic syndrome	11				11
	dulaglutide		4		3	3	10
		Indication
		other indication(s)	4		3	3	10
	dupilumab		8		15	4	27
		Indication
		atopic dermatitis	7		13	4	24
		other indication(s)	1		2		3
	eculizumab		5	2	9	4	20
		Indication
		atypical haemolytic uraemic syndrome	3	2		2	7
		other indication(s)	1			2	3
		Paroxysmal Nocturnal Haemoglobinuria (PNH)	1		9		10
	elexacaftor/tezacaftor/ivacaftor		3	3		1	7
		Indication
		cystic fibrosis (CF)	3	3		1	7
	eltrombopag		13		6	3	22
		Indication
		other indication(s)	7		1	3	11
		thrombocytopaenia	6		5		11
	emicizumab		4		8	1	13
		Indication
		haemophilia A	4		8	1	13
	empagliflozin		5		11	1	17
		Indication
		heart failure			8		8
		other indication(s)	5		3	1	9
	enoxaparin sodium		19		4	6	29
		Indication
		other indication(s)	13		1	1	15
		thrombosis	6		3	5	14
	epoetin alfa		5		1	3	9
		Indication
		other indication(s)	5		1	3	9
	etanercept		12		4	6	22
		Indication
		other indication(s)	12		4	6	22
	everolimus		10		3	1	14
		Indication
		metastatic chromophobe cell renal cell carcinoma	7				7
		other indication(s)	3		3	1	7
	fluoxetine hydrochloride		4		3	2	9
		Indication
		other indication(s)	4		3	2	9
	galcanezumab		2		7		9
		Indication
		migraines	2		7		9
	ganciclovir eye preparations		12		2		14
		Indication
		Cytomegalovirus (CMV) uveitis	12				12
		other indication(s)			2		2
	gemtuzumab ozogamicin		5		3		8
		Indication
		acute myeloid leukaemia (AML)	5		3		8
	ibrutinib		4		21		25
		Indication
		lymphoma			10		10
		other indication(s)	4		11		15
	indomethacin		19		2	1	22
		Indication
		congenital nephrotic syndrome	10				10
		hemicrania	9		1	1	11
		other indication(s)			1		1
	infliximab		35		19	6	60
		Indication
		other indication(s)	24		17	6	47
		sarcoidosis	10		2		12
	inotuzumab ozogamicin		6		3		9
		Indication
		B-Cell Acute Lymphoblastic Leukaemia (B-ALL)	5		2		7
		other indication(s)	1		1		2
	insulin pump		6		1	9	16
		Indication
		other indication(s)	3		1	1	5
		type 1 diabetes	3			8	11
	insulin pump consumables		5			5	10
		Indication
		other indication(s)	3			2	5
		type 1 diabetes	2			3	5
	isotretinoin		16				16
		Indication
		High Risk Neuroblastoma	15				15
		other indication(s)	1				1
	ivabradine		6		14	1	21
		Indication
		inappropriate sinus tachycardia	1		7	1	9
		other indication(s)	5		7		12
	ketamine		30		1		31
		Indication
		other indication(s)			1		1
		palliative pain care	30				30
	ketotifen		5		3		8
		Indication
		other indication(s)	5		3		8
	lacosamide		6		2		8
		Indication
		epilepsy	6		1		7
		other indication(s)			1		1
	lamotrigine		252		83	10	345
		Indication
		epilepsy	192		64	3	259
		mental health	53		17	6	76
		other indication(s)	7		2	1	10
	lenalidomide		27		5	4	36
		Indication
		myelodysplastic syndrome with 5q deletion	14		1	1	16
		other indication(s)	11		4	3	18
	letermovir		6		1		7
		Indication
		cytomegalovirus (CMV)	6		1		7
	levetiracetam		56		1	5	62
		Indication
		seizures	56		1	5	62
	levocarnitine		5		3		8
		Indication
		other indication(s)	5		3		8
	levofloxacin		8		1	1	10
		Indication
		other indication(s)	3				3
		tuberculosis (TB)	5		1	1	7
	linezolid		31		2	1	34
		Indication
		other indication(s)	11		1	1	13
		tuberculosis (TB)	20		1		21
	liraglutide		1		15		16
		Indication
		other indication(s)	1		4		5
		weight loss			11		11
	macitentan		11		3	1	15
		Indication
		other indication(s)	4				4
		Pulmonary arterial hypertension (PAH)	7		3	1	11
	melatonin		1		11	1	13
		Indication
		insomnia	1		6	1	8
		other indication(s)			5		5
	meningococcal (a, c, y and w-135) conjugate vaccine		8				8
		Indication
		meningococcal disease	8				8
	mepolizumab		7		7	3	17
		Indication
		hypereosinophilia	4		3	3	10
		other indication(s)	3		4		7
	methylphenidate hydrochloride		1		6	2	9
		Indication
		other indication(s)	1		6	2	9
	midostaurin		2	1	3	1	7
		Indication
		other indication(s)	2	1	3	1	7
	mitotane		22				22
		Indication
		adrenocortical carcinoma	22				22
	moxifloxacin		16		3	2	21
		Indication
		other indication(s)	16		3	2	21
	multivitamin and mineral supplement		1		5	1	7
		Indication
		other indication(s)	1		5	1	7
	naltrexone hydrochloride		1		8	1	10
		Indication
		other indication(s)	1		8	1	10
	nelarabine		8		2		10
		Indication
		acute lymphocytic leukaemia (ALL)	8		2		10
	nintedanib		1		6	2	9
		Indication
		other indication(s)	1		6	2	9
	nirmatrelvir with ritonavir		1		3	6	10
		Indication
		COVID-19	1		3	6	10
	nivolumab		6		6	1	13
		Indication
		other indication(s)	6		6	1	13
	obinutuzumab		4		3	2	9
		Indication
		other indication(s)	4		3	2	9
	octreotide lar		7		5	3	15
		Indication
		other indication(s)	7		5	3	15
	olanzapine		1		1	18	20
		Indication
		other indication(s)	1		1	7	9
		Schizophrenia				11	11
	olaparib		16		8		24
		Indication
		breast cancer	7		6		13
		other indication(s)	9		2		11
	omalizumab		10		3	3	16
		Indication
		other indication(s)	10		3	3	16
	oral feed liquid		1		10		11
		Indication
		other indication(s)	1		10		11
	oral feed paediatric renal		7				7
		Indication
		renal disease	7				7
	palivizumab		1		4	3	8
		Indication
		other indication(s)				1	1
		prevention of respiratory syncytial virus (RSV)	1		4	2	7
	pazopanib		15		8	1	24
		Indication
		other indication(s)	15		8	1	24
	pegylated interferon alfa-2a		10		3	2	15
		Indication
		Erdheim-Chester disease	7			1	8
		other indication(s)	3		3	1	7
	pegylated liposomal doxorubicin hydrochloride		5		20		25
		Indication
		other indication(s)	5		4		9
		Ovarian Cancer			16		16
	pembrolizumab		26		37	2	65
		Indication
		carcinoma	1		14		15
		Hodgkin's lymphoma	14		1	1	16
		other indication(s)	11		22	1	34
	perampanel		8		5	5	18
		Indication
		epilepsy	8		5	5	18
	ponatinib		10	1	3		14
		Indication
		chronic myeloid leukemia (CML)	6	1	3		10
		other indication(s)	4				4
	posaconazole		36		3	2	41
		Indication
		aspergillus infection	14				14
		mucormycosis	8				8
		other indication(s)	13		3	2	18
	potassium citrate		6		5		11
		Indication
		other indication(s)	6		5		11
		pristinamycin	39		1		40
		Mycoplasma genitalium infection	37		1		38
		other indication(s)	2				2
	prucalopride		18		16	3	37
		Indication
		constipation	4		11	1	16
		gastroparesis	8		5	2	15
		other indication(s)	6				6
	retinol (vitamin a)		425		2	6	433
		Indication
		cystic fibrosis (CF)	45				45
		liver disease or short gut syndrome	310		1	1	312
		other indication(s)	70		1	5	76
	ribavirin		6		1	2	9
		Indication
		other indication(s)	6		1	2	9
	rifaximin		2		7		9
		Indication
		other indication(s)	2		7		9
	rituximab		144		45	24	213
		Indication
		encephalitis	9			3	12
		glomerulonephritis	11		1		12
		interstitial lung disease	8		5	3	16
		leukaemia	4		1		5
		lymphoma	12		1	2	15
		mucous pemphigoid	12		2	1	15
		myositis	8		5		13
		nephrotic syndrome	14		13		27
		other indication(s)	66		17	14	97
	rufinamide		34		1		35
		Indication
		epilepsy	20		1		21
		Lennox-Gastaut syndrome	9				9
		other indication(s)	5				5
	ruxolitinib		22		12	1	35
		Indication
		Graft vs Host Disease	4		5		9
		other indication(s)	11		4	1	16
		VEXAS syndrome	7		3		10
	sargramostim		22				22
		Indication
		High Risk Neuroblastom	19				19
		other indication(s)	3				3
	secukinumab		17		11	3	31
		Indication
		ankylosing spondylitis				1	1
		hidradenitis suppurativa (HS)	7		1		8
		other indication(s)	6		8		14
		psoriasis	4		2	2	8
	selexipag		6		9		15
		Indication
		pulmonary hypertension	6		9		15
		sirolimus	28		2	2	32
		facial angiofibromas	5				5
		other indication(s)	23		2	2	27
	sirolimus		13			1	14
		Indication
		facial angiofibromas	10				10
		other indication(s)	3			1	4
	sitafloxacin		10				10
		Indication
		Mycoplasma genitalium infection	10				10
	sodium chloride		3		13	1	17
		Indication
		hyponatraemia			7		7
		other indication(s)	3		6	1	10
	sofosbuvir with velpatasvir		5		1	1	7
		Indication
		hepatitis C	5		1	1	7
	sorafenib		9		3		12
		Indication
		fibromatosis	7		1		8
		other indication(s)	2		2		4
	stanozolol		35		1		36
		Indication
		hereditary angioedema	35				35
		other indication(s)			1		1
	sunitinib		6		3	2	11
		Indication
		other indication(s)	6		3	2	11
	tacrolimus		13		7	10	30
		Indication
		other indication(s)	13		7	10	30
	tadalafil		11		8	1	20
		Indication
		other indication(s)			2		2
		pulmonary hypertension	11		6	1	18
	taurolidine and citrate		4		5		9
		Indication
		other indication(s)	4		5		9
	temozolomide		29		4		33
		Indication
		neuroblastoma	8				8
		other indication(s)	21		4		25
	teriparatide		5		6		11
		Indication
		other indication(s)	5		6		11
	thalidomide		16		2		18
		Indication
		other indication(s)	16		2		18
	tinidazole		18				18
		Indication
		trichomonas infection	18				18
	tobramycin		1		6	3	10
		Indication
		other indication(s)	1		6	3	10
	tocilizumab		79		22	10	111
		Indication
		COVID-19	46				46
		giant cell arteritis	6		15	1	22
		other indication(s)	27		7	9	43
	tofacitinib		9		10	1	20
		Indication
		other indication(s)	9		5		14
		rheumatoid arthritis			5	1	6
	topotecan		26			1	27
		Indication
		neuroblastoma	22				22
		other indication(s)	4			1	5
	trametinib		47		9	1	57
		Indication
		astrocytoma	12		1		13
		glioma	8				8
		neurofibroma	10		2		12
		other indication(s)	17		6	1	24
	trastuzumab		5		9	1	15
		Indication
		breast cancer	5		1	1	7
		other indication(s)			8		8
	upadacitinib		25		23	2	50
		Indication
		atopic dermatitis	20		6	1	27
		other indication(s)	5		17	1	23
	ursodeoxycholic acid		5		2	2	9
		Indication
		other indication(s)	5		2	2	9
	ustekinumab		7		15	2	24
		Indication
		Crohn's disease	3		9	2	14
		other indication(s)	4		6		10
	valganciclovir		23				23
		Indication
		cytomegalovirus (CMV)	18				18
		other indication(s)	5				5
	varicella zoster vaccine				8	8	16
		Indication
		other indication(s)			3		3
		shingles prevention			5	8	13
	vedolizumab		4		8	1	13
		Indication
		Crohn's disease	3		5	1	9
		other indication(s)	1		3		4
	vemurafenib		6		1	1	8
		Indication
		other indication(s)	6		1	1	8
	venetoclax		14	1	30	3	48
		Indication
		acute myeloid leukaemia (AML)	7		11	1	19
		chronic lymphocytic leukaemia (CLL)	2		4	1	7
		mantle cell lymphoma		1	7		8
		other indication(s)	5		8	1	14
	venlafaxine		1		5	2	8
		Indication
		depression	1		5	2	8
	vinorelbine		8		1		9
		Indication
		other indication(s)	2				2
		rhabdomyosarcoma	6		1		7
	voriconazole		21			2	23
		Indication
		aspergillus infection	8				8
		fungal infection	8			2	10
		other indication(s)	5				5
	zonisamide		44		5		49
		Indication
		epilepsy	44		5		49