NPPA outcome data 2022/23
This is a list of decisions on NPPA applications with their outcomes. We've included the indication where it would not compromise anyone's privacy.
Download the data as a spreadsheet (includes medicines, outcomes and some indications)
- NPPA Data 2022 23 Includes indications [XLSX 29 KB]
Call the team if you have any questions about your particular medicine.
Outcomes of applications by medicine 2022/23
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Medicine | Approved | Declined | Principles not met | Withdrawn application | Total | ||
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adalimumab | 11 | 2 | 13 | |||
Indication | |||||||
chronic recurrent multifocal osteomyelitis | 4 | 4 | |||||
Other indication(s) | 7 | 2 | 9 | ||||
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alpha tocopheryl acetate | 49 | 1 | 50 | |||
Indication | |||||||
cystic fibrosis (CF) | 4 | 4 | |||||
liver disease or short gut syndrome | 36 | 36 | |||||
liver disease or short gut syndrome, Biliary Atresia | 1 | 1 | |||||
Liver disease, EBV infection, Oral liquid required (child) | 1 | 1 | |||||
other indication(s) | 7 | 1 | 8 | ||||
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anakinra | 9 | 1 | 10 | |||
Indication | |||||||
other indication(s) | 9 | 1 | 10 | ||||
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asparaginase | 7 | 7 | ||||
Indication | |||||||
ALL | 4 | 4 | |||||
other indication(s) | 3 | 3 | |||||
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atezolizumab | 6 | 1 | 7 | |||
Indication | |||||||
Other indication(s) | 6 | 1 | 7 | ||||
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azacitidine | 5 | 5 | ||||
Indication | |||||||
Other indication(s) | 5 | 5 | |||||
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azithromycin | 1 | 1 | 2 | 4 | ||
Indication | |||||||
Other indication(s) | 1 | 1 | 2 | 4 | |||
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bedaquiline | 11 | 11 | ||||
Indication | |||||||
Multi-drug resistant (MDR) tuberculosis (TB) | 5 | 5 | |||||
Other indication(s) | 6 | 6 | |||||
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bevacizumab | 9 | 6 | 15 | |||
Indication | |||||||
Other indication(s) | 9 | 6 | 15 | ||||
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biotin | 6 | 6 | ||||
Indication | |||||||
Other indication(s) | 6 | 6 | |||||
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blinatumomab | 7 | 1 | 8 | |||
Indication | |||||||
B-ALL | 4 | 1 | 5 | ||||
Other indication(s) | 3 | 3 | |||||
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brentuximab vedotin | 17 | 1 | 18 | |||
Indication | |||||||
Other indication(s) | 4 | 4 | |||||
relapsed/refractory CD30-positive Hodgkin lymphona | 13 | 1 | 14 | ||||
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canakinumab | 4 | 4 | ||||
Indication | |||||||
Other indication(s) | 4 | 4 | |||||
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cannabinoid | 3 | 10 | 1 | 14 | ||
Indication | |||||||
Epilepsy | 3 | 1 | 4 | ||||
Other indication(s) | 3 | 7 | 10 | ||||
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ciclosporin eye preparations | 85 | 1 | 1 | 87 | ||
Indication | |||||||
allergic conjunctivitis | 2 | 2 | |||||
allergic conjunctivitis, keratoconjunctivitis sicca | 1 | 1 | |||||
allergic eye disease | 2 | 2 | |||||
allergic eye disease, limbitis, reactive fibrovascular growth to temporal conjunctiva | 1 | 1 | |||||
allergic eye disease, Sjogren's syndrome | 1 | 1 | |||||
allergic keratoconjunctivitis | 1 | 1 | |||||
allergic keratoconjunctivitis, giant papillarly conjunctivitis | 1 | 1 | |||||
atopic conjunctivitis | 1 | 1 | |||||
atopic conjunctivitis, allergic conjunctivitis | 2 | 2 | |||||
atopic keratoconjunctivitis | 4 | 1 | 5 | ||||
atopic keratoconjunctivitis, limbitis | 1 | 1 | |||||
bilateral keratoconus, corneal graft, giant papillarly conjunctivitis | 1 | 1 | |||||
Bilateral Superior Conjunctival Epithelium Growth | 1 | 1 | |||||
Blepharitis, ocular rosacea, meibomian gland dysfunction | 1 | 1 | |||||
blepharokeratoconjunctivitis | 2 | 2 | |||||
corneal neovascularisation | 1 | 1 | |||||
dry eyes | 1 | 1 | |||||
dry eyes, ocular surface inflammation | 1 | 1 | |||||
dry eyes, ocular surface inflammation, NOT RARE DISORDER - REPORTING PURPOSES ONLY | 1 | 1 | |||||
Graft vs Host Disease | 1 | 1 | |||||
Inferior punctuate erosions | 1 | 1 | |||||
keratoconjunctivitis sicca | 5 | 5 | |||||
keratoconjunctivitis sicca, allergic conjunctivitis | 1 | 1 | |||||
keratoconjunctivitis sicca, dry eyes | 1 | 1 | |||||
keratoconjunctivitis sicca, severe dry eye | 2 | 2 | |||||
keratoconjunctivitis sicca, severe dry eyes | 2 | 2 | |||||
keratoconjunctivitis sicca, Sjogren's syndrome | 2 | 2 | |||||
marginal keratitis, Blepharitis, meibomian gland dysfunction | 1 | 1 | |||||
meibomian gland dysfunction | 1 | 1 | |||||
neuropathic keratopathy, corneal scarring | 1 | 1 | |||||
ocular graft vs host disease | 1 | 1 | |||||
ocular inflammation | 1 | 1 | |||||
other indication(s) | 1 | 1 | |||||
rosacea keratitis | 1 | 1 | |||||
severe allergic conjunctivitis | 2 | 2 | |||||
severe dry eye | 1 | 1 | |||||
severe dry eye, NOT RARE DISORDER - REPORTING PURPOSES ONLY | 1 | 1 | |||||
severe dry eyes, Sjogren's syndrome | 1 | 1 | |||||
severe keratoconjunctivitis sicca | 3 | 3 | |||||
Severe ocular rosacea | 1 | 1 | |||||
severe secretory dry eye | 4 | 4 | |||||
severe secretory dry eye, connective tissue disorder, Sjogren's syndrome | 1 | 1 | |||||
severe secretory dry eye, NOT RARE DISORDER - REPORTING PURPOSES ONLY | 1 | 1 | |||||
severe secretory dry eye, rheumatoid arthritis, Sjogren's syndrome | 1 | 1 | |||||
severe secretory dry eye, RhF positive | 1 | 1 | |||||
vernal blepharoconjunctivitis | 1 | 1 | |||||
vernal conjunctivitis, keratitis, veratoconus | 1 | 1 | |||||
vernal keratoconjunctivitis (VKC) | 19 | 19 | |||||
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cinacalcet | 2 | 2 | 4 | |||
Indication | |||||||
other indication(s) | 2 | 2 | 4 | ||||
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continuous glucose monitoring system | 8 | 6 | 2 | 16 | ||
Indication | |||||||
Other indication(s) | 7 | 1 | 2 | 10 | |||
type 1 diabetes | 1 | 5 | 6 | ||||
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dabrafenib | 5 | 1 | 6 | |||
Indication | |||||||
other indication(s) | 5 | 1 | 6 | ||||
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dasatinib | 3 | 1 | 4 | |||
Indication | |||||||
Other indication(s) | 3 | 1 | 4 | ||||
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deferasirox | 4 | 2 | 1 | 7 | ||
Indication | |||||||
iron overload | 3 | 1 | 4 | ||||
Other indication(s) | 1 | 1 | 1 | 4 | |||
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denosumab | 5 | 5 | 10 | |||
Indication | |||||||
Giant cell tumour of the bone | 4 | 1 | 5 | ||||
Other indication(s) | 1 | 4 | 5 | ||||
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dupilumab | 3 | 1 | 4 | |||
Indication | |||||||
Other indication(s) | 3 | 1 | 4 | ||||
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eculizumab | 2 | 1 | 1 | 1 | 5 | |
Indication | |||||||
Other indication(s) | 2 | 1 | 1 | 1 | 5 | ||
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eltrombopag | 3 | 1 | 4 | |||
Indication | |||||||
Other indication(s) | 3 | 1 | 4 | ||||
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enoxaparin sodium | 4 | 2 | 6 | |||
Indication | |||||||
Other indication(s) | 4 | 2 | 6 | ||||
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etanercept | 2 | 1 | 1 | 4 | ||
Indication | |||||||
Other indication(s) | 2 | 1 | 1 | 4 | |||
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fenfluramine | 3 | 1 | 4 | |||
Indication | |||||||
dravet's syndrome | 3 | 1 | 4 | ||||
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galcanezumab | 1 | 3 | 4 | |||
Indication | |||||||
chronic migraine | 1 | 3 | 4 | ||||
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ganciclovir eye preparations | 4 | 4 | ||||
Indication | |||||||
Cytomegalovirus (CMV) uveitis | 4 | 4 | |||||
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ibrutinib | 1 | 6 | 7 | |||
Indication | |||||||
other indication(s) | 1 | 6 | 7 | ||||
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imiglucerase | 5 | 5 | ||||
Indication | |||||||
Gaucher's Disease | 5 | 5 | |||||
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indomethacin | 4 | 4 | ||||
Indication | |||||||
other indication(s) | 4 | 4 | |||||
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infliximab | 7 | 4 | 11 | |||
Indication | |||||||
Other indication(s) | 7 | 4 | 11 | ||||
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inotuzumab ozogamicin | 4 | 4 | ||||
Indication | |||||||
Other indication(s) | 4 | 4 | |||||
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insulin pump consumables | 3 | 4 | 7 | |||
Indication | |||||||
other indication(s) | 1 | 2 | 3 | ||||
Type 1 diabetes | 2 | 2 | 4 | ||||
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ivabradine | 1 | 4 | 1 | 6 | ||
Indication | |||||||
atrial tachycardias | 1 | 1 | |||||
inappropriate sinus tachycardia | 4 | 1 | 5 | ||||
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ketamine | 8 | 8 | ||||
Indication | |||||||
pallative care pain | 8 | 8 | |||||
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lamotrigine | 10 | 5 | 1 | 16 | ||
Indication | |||||||
Epilepsy | 10 | 3 | 1 | 14 | |||
Other indication(s) | 2 | 2 | |||||
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lenalidomide | 6 | 1 | 7 | |||
Indication | |||||||
myelodysplastic syndrome with 5q deletion | 4 | 4 | |||||
Other indication(s) | 2 | 1 | 3 | ||||
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levetiracetam | 31 | 1 | 32 | |||
Indication | |||||||
palliative care, Seizures | 31 | 1 | 32 | ||||
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levocarnitine | 2 | 1 | 3 | |||
Indication | |||||||
other indication(s) | 2 | 1 | 3 | ||||
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linezolid | 7 | 1 | 8 | |||
Indication | |||||||
Multi-drug resistant (MDR) tuberculosis (TB) | 6 | 6 | |||||
Other indication(s) | 1 | 1 | 2 | ||||
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liraglutide | 6 | 6 | ||||
Indication | |||||||
Obesity, high BMI | 6 | 6 | |||||
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macitentan | 7 | 3 | 1 | 11 | ||
Indication | |||||||
other indication(s) | 2 | 2 | |||||
Pulmonary hypertension (PAH) | 5 | 3 | 1 | 9 | |||
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melatonin | 4 | 4 | ||||
Indication | |||||||
other indication(s) | 4 | 4 | |||||
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mepolizumab | 2 | 2 | 4 | |||
Indication | |||||||
other indication(s) | 2 | 2 | 4 | ||||
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mitotane | 10 | 10 | ||||
Indication | |||||||
adrenocortical carcinoma | 10 | 10 | |||||
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moxifloxacin | 4 | 1 | 1 | 6 | ||
Indication | |||||||
other indication(s) | 4 | 1 | 1 | 6 | |||
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nelarabine | 4 | 1 | 5 | |||
Indication | |||||||
Acute Lymphocytic leukaemia | 4 | 1 | 5 | ||||
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nirmatrelvir with ritonavir | 1 | 2 | 5 | 8 | ||
Indication | |||||||
COVID-19 | 1 | 2 | 5 | 8 | |||
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octreotide lar | 4 | 1 | 5 | |||
Indication | |||||||
Other indication(s) | 4 | 1 | 5 | ||||
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olaparib | 12 | 1 | 13 | |||
Indication | |||||||
BRCA2 mutation, metastatic breast cancer | 5 | 5 | |||||
Other indication(s) | 7 | 1 | 8 | ||||
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omalizumab | 2 | 1 | 1 | 4 | ||
Indication | |||||||
Other indication(s) | 2 | 1 | 1 | 4 | |||
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pazopanib | 3 | 2 | 5 | |||
Indication | |||||||
Other indication(s) | 3 | 2 | 5 | ||||
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pembrolizimab | 9 | 11 | 1 | 21 | ||
Indication | |||||||
other indication(s) | 2 | 11 | 1 | 14 | |||
placental trophoblastic tumour | 1 | 1 | |||||
relapsed Hodgkin's lymphoma | 6 | 6 | |||||
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pirfenidone | 1 | 3 | 4 | |||
Indication | |||||||
other indication(s) | 1 | 3 | 4 | ||||
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posaconazole | 9 | 1 | 10 | |||
Indication | |||||||
Other indication(s) | 9 | 1 | 10 | ||||
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pristinamycin | 7 | 7 | ||||
Indication | |||||||
Mycoplasma genitalium infection | 6 | 6 | |||||
Other indication(s) | 1 | 1 | |||||
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prucalopride | 6 | 6 | 1 | 13 | ||
Indication | |||||||
chronic constipation | 5 | 5 | |||||
severe gastroparesis | 6 | 1 | 1 | 8 | |||
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retinol (vitamin a) | 55 | 55 | ||||
Indication | |||||||
liver disease or short gut syndrome | 46 | 46 | |||||
other indication(s) | 9 | 9 | |||||
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rituximab | 26 | 5 | 3 | 34 | ||
Indication | |||||||
Other indication(s) | 26 | 5 | 3 | 34 | |||
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rufinamide | 7 | 1 | 8 | |||
Indication | |||||||
Other indication(s) | 1 | 1 | |||||
refractory epilepsy | 6 | 1 | 7 | ||||
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ruxolitinib | 4 | 2 | 6 | |||
Indication | |||||||
Graft versus host disease | 3 | 2 | 5 | ||||
Other indication(s) | 1 | 1 | |||||
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sargramostim | 4 | 4 | ||||
Indication | |||||||
High risk neuroblastom | 4 | 4 | |||||
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secukinumab | 7 | 3 | 10 | |||
Indication | |||||||
Other indication(s) | 7 | 3 | 10 | ||||
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sirolimus | 4 | 4 | ||||
Indication | |||||||
Other indication(s) | 4 | 4 | |||||
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sunitinib | 2 | 1 | 1 | 4 | ||
Indication | |||||||
Other indication(s) | 2 | 1 | 1 | 4 | |||
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tacrolimus ointment | 1 | 4 | 5 | |||
Indication | |||||||
other indication(s) | 1 | 4 | 5 | ||||
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tadalafil | 3 | 3 | 1 | 7 | ||
Indication | |||||||
Other indication(s) | 1 | 1 | |||||
Pulmonary arterial hypertension (PAH) | 2 | 3 | 1 | 6 | |||
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temozolomide | 10 | 3 | 13 | |||
Indication | |||||||
Highr risk neuroblastoma | 4 | 4 | |||||
other indication(s) | 6 | 3 | 9 | ||||
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thalidomide | 4 | 1 | 5 | |||
Indication | |||||||
other indication(s) | 4 | 1 | 5 | ||||
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tocilizumab | 7 | 9 | 1 | 17 | ||
Indication | |||||||
Giant cell arteritis | 1 | 4 | 5 | ||||
Other indication(s) | 6 | 5 | 1 | 12 | |||
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topotecan | 5 | 5 | ||||
Indication | |||||||
High risk neuroblastoma | 5 | 5 | |||||
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trametinib | 16 | 1 | 1 | 18 | ||
Indication | |||||||
neurofibromatosis type 1 | 4 | 1 | 5 | ||||
Other indication(s) | 12 | 1 | 13 | ||||
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upadacitinib | 12 | 5 | 1 | 18 | ||
Indication | |||||||
Other indication(s) | 3 | 3 | 1 | 7 | |||
severe atopic dermatitis | 9 | 2 | 11 | ||||
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ustekinumab | 1 | 3 | 4 | |||
Indication | |||||||
Other indication(s) | 1 | 3 | 4 | ||||
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valganciclovir | 4 | 4 | ||||
Indication | |||||||
Cytomegalovirus (CMV) | 4 | 4 | |||||
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varicella zoster virus | 5 | 1 | 6 | |||
Indication | |||||||
shingles prevention | 5 | 1 | 6 | ||||
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venetoclax | 5 | 5 | 1 | 11 | ||
Indication | |||||||
Acute myeloid leukaemia (AML) | 3 | 1 | 4 | ||||
Other indication(s) | 2 | 5 | 7 | ||||
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voriconazole | 7 | 1 | 8 | |||
Indication | |||||||
chronic aspergillosis | 4 | 4 | |||||
Other indication(s) | 3 | 1 | 4 | ||||
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zonisamide | 8 | 1 | 9 | |||
Indication | |||||||
refractory epilepsy | 8 | 1 | 9 | ||||