NPPA outcome data 2021/22

This is a list of decisions on NPPA applications with their outcomes. We've included the indication where it would not compromise anyone's privacy.

Download the data as a spreadsheet (includes medicines, outcomes and some indications)

NPPA Data 2021 22 Includes indications [XLSX 29 KB]

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Outcomes of applications by medicine 2021/22

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Medicine		Approved	Declined	Principles not met	Withdrawn application	Total
acetic acid		1				1
acetylcysteine		1			1	2
adalimumab		3		2	3	8
	Indication
	Anxiety			1		1
	Crohn's disease				1	1
	Type 1 diabetes				1	1
	Other indication(s)	3		1	1	5

adalimumab (Amgevita)		1				1
aflibercept				1		1
alectinib				1	1	2
alglucosidase alfa				2		2
alirocumab				1	1	2
alitretinoin				3		3
	Indication
	Dermatitis			2		2
	Other indication(s)			1		1

alpha tocopheryl acetate		2				2
	Indication
	Pancreatic insufficiency	2				2

alpha tocopheryl acetate (Micelle E)					1	1
amantadine hydrochloride		1				1
ambrisentan					1	1
	Indication
	Pulmonary hypertension				1	1

amifampridine [3,4-diaminopyridine]		2				2
amikacin		1				1
amiloride hydrochloride					1	1
amino acid formula (without isoleucine, leucine and valine)		6				6
	Indication
	Short-chain enoyl-CoA hydratase deficiency	4				4
	Leigh syndrome	2				2

amino acid formula (without methionine) (hcu lophlex lq20)				1		1
amino acid formula low calcium (Locasol)		4				4
	Indication
	Hypercalcaemia	4				4

anakinra		5		1	1	7
apixaban				1		1
aprepitant		3		1	1	5
	Indication
	Intractable nausea	3			1	4
	Other indication(s)			1		1

arginine		1				1
aripiprazole				1		1
	Indication
	Schizoaffective Disorder			1		1

aripiprazole				1		1
asfotase alpha		1				1
asparaginase (Erwinase)		1				1
atezolizumab				6		6
	Indication
	Metastatic colon cancer			2		2
	Other indication(s)			4		4

atovaquone		1				1
azacitidine		9		1	1	11
	Indication
	Acute myeloid leukaemia (AML)			1		1
	Chronic myelomonocytic leukemia (CMML)	1			1	2
	Myelodysplasia	3				3
	Other indication(s)	5				5

azithromycin				2	1	3
	Indication
	Cystic fibrosis (CF)			1		1
	Other indication(s)			1	1	2

bedaquiline		8			1	9
	Indication
	Multi-drug resistant (MDR) tuberculosis (TB)	6			1	7
	Other indication(s)	2				2

belimumab				3		3
	Indication
	Lupus nephritis			2		2
	Other indication(s)			1		1

bendamustine hydrochloride		1		1		2
bevacizumab		2		1	1	4
	Indication
	Ovarian Cancer			1		1
	Other indication(s)	2			1	3

bilastine				1		1
bimatoprost preservative free				1		1
biotin		1				1
blinatumomab		3				3
	Indication
	B-Cell Acute Lymphoblastic Leukaemia	3				3

bortezomib		2				2
	Indication
	Epstein Barr Virus	1				1
	Other indication(s)	1				1

bosutinib		1				1
	Indication
	Chronic myeloid leukemia (CML)	1				1

brentuximab vedotin		2		3		5
bromocriptine					1	1
bromocriptine mesylate		1				1
budesonide		2		2		4
buprenorphine				1		1
burosumab				2		2
cannabinoid		1		7	1	9
	Indication
	Anxiety			2		2
	Epilepsy			1		1
	Other indication(s)	1		4	1	6

cefiderocol		2				2
ceftazidime and avibactam					1	1
ceftolozane/tazobactam		1				1
chloramphenicol					1	1
ciclosporin eye preparations		56		1	1	58
	Indication
	Atopic keratoconjunctivitis	5				5
	Dry eyes	3			1	4
	Keratoconjunctivitis sicca	16				16
	Ocular inflammation	2				2
	Reis-Bucklers corneal dystrophy	4				4
	Severe dry eyes	6				6
	Sjogren's syndrome	4		1		5
	Vernal keratoconjunctivitis (VKC)	7				7
	Other indication(s)	9				9

cinacalcet		2		5		7
	Indication
	Hypercalcaemia	1				1
	Hyperparathyroidism	1		5		6

citrulline		1				1
clofarabine					1	1
	Indication
	Acute myeloid leukaemia (AML)				1	1

cobimetinib					1	1
	Indication
	Metastatic melanoma				1	1

coenzyme q10					1	1
colesevelam				1		1
colistin sulphomethate					1	1
continuous glucose monitoring system (Dexcom glucose transmitters and sensors)				2	1	3
	Indication
	Type 1 diabetes			1	1	2
	Other indication(s)			1		1

continuous glucose monitoring system (Dexcom g6 alarmed interstitial glucose sensor)				1		1
continuous glucose monitoring system (Dexcom G6 sensors)		1				1
continuous glucose monitoring system (Dexcom G6 transmitter)		1				1
continuous glucose monitoring system (Dexcom)				2		2
	Indication
	Type 1 diabetes			2		2

continuous glucose monitoring system (Freestyle Libre)				1		1
	Indication
	Anxiety			1		1

continuous glucose monitoring system (FreeStyle Libre: Flash Glucose Monitoring System)		1				1
continuous glucose monitoring system (Guardian Connect transmitter)		1				1
continuous glucose monitoring system (Guardian Sensor 3)		1				1
cyanocobalamin (Vitamin B12)				1		1
cyclopentolate eye preperations		1				1
dabrafenib				3		3
	Indication
	Metastatic melanoma			2		2
	Ovarian Cancer			1		1

danazol		4				4
	Indication
	Hereditary angioedema	2				2
	Other indication(s)	2				2

daratumumab				1		1
deferasirox				1	2	3
deferiprone		2				2
degarelix				1		1
demeclocycline hydrochloride		1		1		2
	Indication
	Hyponatraemia	1				1
	Other indication(s)			1		1

denosumab		5		4	1	10
	Indication
	Giant cell tumour of the bone	5				5
	Hypercalcaemia			1		1
	Osteoporosis			3		3
	Other indication(s)				1	1

desogestrel				1		1
	Indication
	Other indication(s)			1		1

dexamethasone eye preparations (Ozurdex)				2		2
diphenoxylate hydrochloride with atropine sulphate				1		1
dipyridamole		4				4
	Indication
	Nephrotic Syndrome	4				4

dulaglutide		1		1	1	3
	Indication
	Type 2 diabetes				1	1
	Other indication(s)	1		1		2

duloxetine				1		1
	Indication
	Anxiety			1		1

dupilumab				2	1	3
	Indication
	Dermatitis			1	1	2
	Other indication(s)			1		1

eculizumab		2			1	3
elexacaftor/tezacaftor/ivacaftor				1		1
eltrombopag		1		3	1	5
emicizumab		2		1		3
emollient (Octenisan)				1		1
empagliflozin				5		5
	Indication
	Heart failure			3		3
	Type 2 diabetes			2		2

emtricitabine with tenofovir alafenamide				2		2
enoxaparin sodium		4			2	6
enteral feed (Liquid Hope)				1		1
enteral feed paediatric (Compleat)		1				1
entrectinib				1		1
	Indication
	Ovarian Cancer			1		1

eplerenone		1		1		2
epoetin alfa				1	1	2
	Indication
	Chronic myelomonocytic leukemia (CMML)				1	1
	Other indication(s)			1		1

eptacog alfa [recombinant factor viia]		1				1
erenumab				1		1
eribulin				1		1
	Indication
	Breast cancer			1		1

etanercept		2		1	1	4
etoricoxib				2		2
everolimus		1		1		2
	Indication
	Neuroendocrine tumour			1		1
	Other indication(s)	1				1

evolocumab		1		2		3
fexofenadine hydrochloride		1				1
filgrastim					1	1
fish oil (PharmEPA Complete)				1		1
flunarizine		1				1
fluoxetine hydrochloride		1		1		2
	Indication
	Anxiety	1				1
	Depression			1		1

fluphenazine decanoate		1				1
	Indication
	Schizophrenia	1				1

fluvoxamine maleate				1		1
fostamatinib		1				1
gabapentin		1		2		3
	Indication
	Epilepsy	1				1
	Other indication(s)			2		2

ganciclovir		1				1
	Indication
	Cytomegalovirus (CMV)	1				1

ganciclovir eye preparations		3		1		4
	Indication
	Cytomegalovirus (CMV)	3				3
	Other indication(s)			1		1

gemtuzumab ozogamicin				2		2
	Indication
	Acute myeloid leukaemia (AML)			1		1
	Other indication(s)			1		1

glycopyrrolate					1	1
goserelin (Zoladex)				1		1
	Indication
	Breast cancer			1		1

hydrocortisone acetate (rectal foam) (Cortifoam)					1	1
ibrutinib				2	1	3
icatibant		1				1
idebenone		1				1
indomethacin		5				5
	Indication
	Nephrotic Syndrome	4				4
	Other indication(s)	1				1

infliximab		7		3	2	12
	Indication
	Chronic lymphocytic leukaemia (CLL)	1				1
	Crohn's disease	1				1
	Ulcerative Colitis			1		1
	Other indication(s)	4		2	2	8
	Anxiety	1				1

insulin pump		1			2	3
	Indication
	Type 1 diabetes	1			2	3

ipilimumab				1		1
i-port (I-Port)				1		1
	Indication
	Type 2 diabetes			1		1

isoleucine		2				2
	Indication
	Leigh syndrome	1				1
	Short-chain enoyl-CoA hydratase deficiency	1				1

ivabradine		3		3		6
	Indication
	Heart failure	1				1
	Other indication(s)	2		3		5

ketamine		5		1		6
	Indication
	Pain management	4				4
	Other indication(s)	1		1		2

ketotifen		2				2
lamotrigine		2	1	15	2	20
	Indication
	Epilepsy	2	1	10		11
	Mental health			3	2	5
	Other indication(s)			2		2

lanadelumab		1		1		2
	Indication
	Hereditary angioedema	1		1		2

lanreotide		2			1	3
	Indication
	Neuroendocrine tumour	1			1	2
	Other indication(s)	1				1

lenalidomide		4		3		7
	Indication
	Myelodysplasia	1		3		4
	Other indication(s)	3				3

lenolidamide					1	1
lenvatinib				1		1
letermovir		2				2
	Indication
	Cytomegalovirus (CMV)	2				2

leucine		2				2
	Indication
	Leigh syndrome	1				1
	Short-chain enoyl-CoA hydratase deficiency	1				1

leuprorelin acetate				1		1
levetiracetam		2		1		3
	Indication
	Epilepsy			1		1
	Other indication(s)	2				2

levocarnitine				1		1
	Indication
	Epilepsy			1		1

levocarnitine (Carnitor)		1				1
levocetirizine				1		1
levofloxacin		1				1
	Indication
	Multi-drug resistant (MDR) tuberculosis (TB)	1				1

levofloxacin (Dr Reddy's)				1		1
lidocaine [lignocaine]				1		1
linezolid		8				8
	Indication
	Cystic fibrosis (CF)	1				1
	Multi-drug resistant (MDR) tuberculosis (TB)	5				5
	Other indication(s)	2				2

liraglutide				1		1
	Indication
	Anxiety			1		1

luspatercept				1		1
macitentan		2				2
	Indication
	Pulmonary hypertension	2				2

megestrol acetate		1				1
melatonin		1		2		3
mepolizumab		3				3
methylphenidate hydrochloride		1		1		2
metolazone					1	1
	Indication
	Heart failure				1	1

metronidazole		1				1
	Indication
	Breast cancer	1				1

midostaurin		1	1	1		3
	Indication
	Acute myeloid leukaemia (AML)	1				1
	Other indication(s)		1	1		2

migalastat					1	1
miglustat		3				3
mirabegron				1		1
mitotane		2				2
moxifloxacin		3				3
	Indication
	Multi-drug resistant (MDR) tuberculosis (TB)	3				3

multiple sclerosis					1	1
multivitamin and mineral supplement (Clinicians Multivitamin and Mineral Boost)				1		1
mycophenolic acid					1	1
naltrexone hydrochloride				1		1
nelarabine				1		1
nimodipine					2	2
nintedanib				1	1	2
	Indication
	Lung Disease			1		1
	Other indication(s)				1	1

nirmatrelvir with ritonavir (Paxlovid)					1	1
	Indication
	COVID-19				1	1

nitazoxanide (Alinia)					1	1
nivolumab				3	1	4
	Indication
	Metastatic colon cancer			1		1
	Other indication(s)			2	1	3

octreotide lar		3		2		5
	Indication
	Neuroendocrine tumour	3				3
	Other indication(s)			2		2

oestradiol				1		1
oestradiol valerate				1		1
olanzapine (Zyprexa Zydis)		1				1
omadacycline		1				1
	Indication
	Cystic fibrosis (CF)	1				1

omeprazole				1		1
oral feed liquid (Fortisip or Ensure Plus)		1				1
oral feed liquid fat-free (Fortijuce)				2		2
oral feed paediatric renal (Renastart)		7				7
	Indication
	Renal disease	7				7

oral supplement elemental with high medium chain triglyceride (Emsogen)		1				1
orlistat				1		1
oseltamivir		1				1
oxandrolone					1	1
oxcarbazepine (Trileptal)				1		1
oxybutynin		1				1
palbociclib			1			1
paliperidone				5		5
	Indication
	Schizoaffective Disorder			1		1
	Schizophrenia			2		2
	Other indication(s)			2		2

palivizumab		1		3	2	6
	Indication
	Heart failure	1				1
	Other indication(s)			3	2	5

paracetamol					1	1
paraldehyde		1				1
	Indication
	Epilepsy	1				1

parecoxib		1				1
paromomycin					3	3
	Indication
	Metronidazole resistant trichomoniasis				1	1
	Other indication(s)				2	2

paroxetine				1		1
pazopanib		3		1	1	5
pegylated interferon alfa-2a		3		1		4
	Indication
	Chronic myeloid leukemia (CML)			1		1
	Other indication(s)	3

pegylated interferon		1				1
pegylated liposomal doxorubicin hydrochloride		1		3		4
	Indication
	Ovarian Cancer			3		3
	Other indication(s)	1				1

pembrolizimab		6		10		16
	Indication
	Metastatic colon cancer			3		3
	Other indication(s)	6		7		13

perampanel				4		4
	Indication
	Epilepsy			3		3
	Other indication(s)			1		1

pertuzumab				1	1	2
	Indication
	Breast cancer			1	1	2

phenelzine sulphate		1				1
	Indication
	Depression	1				1

pimecrolimus				1		1
pirfenidone		1				1
plerixafor					1	1
polatuzumab vedotin			1			1
ponatinib		3		1		4
	Indication
	Chronic myeloid leukemia (CML)	2		1		3
	Other indication(s)	1				1

posaconazole		8			1	9
	Indication
	Acute myeloid leukaemia (AML)				1	1
	Aspergillus fumigatus	1				1
	Other indication(s)	7				7

potassium chloride				1		1
potassium citrate				2		2
prednisolone sodium phosphate		1				1
pristinamycin		9				9
	Indication
	Mycoplasma genitalium infection	5				5
	Treatment resistant Mycoplasma genitalium infection	3				3
	Other indication(s)	1				1

probiotics				1		1
	Indication
	Pain management			1		1

prucalopride		2		2	1	5
	Indication
	Hyperparathyroidism	1				1
	Other indication(s)	1		2	1	4

quinacrine [mepacrine]		1		2		3
quinidine		1				1
rasburicase		1				1
retinol				1		1
ribavirin		1			2	3
rifaximin				1		1
riluzole		1				1
risankizumab				1		1
	Indication
	Severe chronic plaque psoriasis			1		1

risdiplam				1		1
rituximab		38		7	5	45
	Indication
	Chronic lymphocytic leukaemia (CLL)	1				1
	Chronic myeloid leukemia (CML)	1				1
	Epilepsy	1				1
	Epstein Barr Virus	1				1
	Lung Disease				1	1
	Lupus nephritis	2				2
	Nephrotic Syndrome			4		4
	Ocular inflammation	1				1
	Other indication(s)	31		3	4	34

rivastigmine				1		1
romiplostim		2				2
rosuvastatin				1		1
rufinamide		11				11
	Indication
	Epilepsy	8				8
	Other indication(s)	3				3

ruxolitinib		3		2		5
	Indication
	Graft versus host disease	1		1		2
	Other indication(s)	2		1		3

sapropterin dihydrochloride				1		1
secukinumab		3		1	2	6
	Indication
	Chronic lymphocytic leukaemia (CLL)	1				1
	Severe chronic plaque psoriasis				1	1
	Other indication(s)	2		1	1	4

selegiline hydrochloride				1		1
selexipag		2				2
	Indication
	Cystic fibrosis (CF)	1				1
	Pulmonary hypertension	1				1

selumetinib				1		1
sildenafil				1		1
	Indication
	Pulmonary hypertension			1		1

sirolimus		2		2		4
	Indication
	Epstein Barr Virus	1				1
	Other indication(s)	1		2		3

sirolimus ointment		6				6
	Indication
	Facial angiofibromas	5				5
	Other indication(s)	1				1

sitafloxacin		1				1
	Indication
	Treatment resistant Mycoplasma genitalium infection	1				1

sodium benzoate		1				1
sodium chloride				4	1	5
	Indication
	Epilepsy			1		1
	Hyponatraemia			2		2
	Other indication(s)			1	1	2

sodium phenylbutyrate				1		1
sofosbuvir with velpatasvir		2				2
somatropin		1				1
spiramycin					1	1
stanozolol		4				4
	Indication
	Hereditary angioedema	4				4

sulthiame		1				1
sunitinib		1				1
tacrolimus		4				3
	Indication
	Graft versus host disease	1				1
	Other indication(s)	3				2

tacrolimus ointment				1		1
	Indication
	Dermatitis			1		1

tacrolimus suppositories				1		1
tadalafil		3		1		4
	Indication
	Depression	1				1
	Other indication(s)	2		1		3

tafamidis				1		1
taurolidine and citrate		2		1		3
teduglutide		1		1		2
temozolomide		2				2
tenofovir alafenamide				1		1
terazosin				1		1
terbutaline					1	1
teriparatide		1		3		4
	Indication
	Osteoporosis			2		2
	Other indication(s)	1		1		2

tetracycline					1	1
thalidomide		3				3
ticagrelor				3		3
tinidazole		5				5
	Indication
	Metronidazole resistant trichomoniasis	2				2
	Other indication(s)	3				3

tirofiban		1				1
tizanidine				1		1
tobramycin				2	1	3
tocilizumab		48		3	4	55
	Indication
	COVID-19	44			1	45
	Giant cell arteritis	1		3	1	5
	Lung Disease				1	1
	Other indication(s)	3			1	4

tofacitinib		1		2	1	4
topotecan					1	1
trametinib		1		3		4
	Indication
	Metastatic melanoma			2		2
	Ovarian Cancer			1		1
	Other indication(s)	1				1

trastuzumab subcutaneous		1				1
	Indication
	Breast cancer	1				1

trientine hydrochloride		1				1
triiodothyroacetic acid		1				1
tyrosine		2				2
upadacitinib				2		2
	Indication
	Dermatitis			1		1
	Other indication(s)			1		1

uridine		2				2
ursodeoxycholic acid		1				1
ustekinumab		3		8	2	13
	Indication
	Crohn's disease	2		5	2	9
	Severe chronic plaque psoriasis			1		1
	Ulcerative Colitis			1		1
	Other indication(s)	1		1		2

valganciclovir		8				8
	Indication
	Cytomegalovirus (CMV)	7				7
	Epstein Barr Virus	1				1

vancomycin		1				1
varicella zoster virus (oka strain) live attenuated vaccine [shingles vaccine] (Zostavax)					1	1
vedolizumab		1		3	1	5
	Indication
	Crohn's disease	1		1		2
	Ulcerative Colitis			1		1
	Other indication(s)			1	1	2

vemurafenib					1	1
	Indication
	Metastatic melanoma				1	1

venetoclax		2		3		5
	Indication
	Acute myeloid leukaemia (AML)			2		2
	Chronic lymphocytic leukaemia (CLL)	1				1
	Other indication(s)	1		1		2

venlafaxine				1		1
	Indication
	Depression			1		1

vinorelbine		1				1
	Indication
	Breast cancer	1				1

vitamin a - retinol		1				1
	Indication
	Pancreatic insufficiency	1				1

voriconazole		7				7
	Indication
	Aspergillus fumigatus	3				3
	Other indication(s)	4				4

whole thyroid extract				1		1
zonisamide		11		1		12
	Indication
	Epilepsy	10		1		11
	Other indication(s)	1				1